Endocrine Abstracts

Rationale/Objective: Diabetes Mellitus (DM) and Interstitial lung Disease (ILD) share common pathogenetic pathways involving inflammatory cells and in particular monocytes and macrophages. Diabetic patients are at higher risk of developing pulmonary fibrosis, whereas DM is a major comorbidity in ILD patients. In our study, we analyzed retrospectively patients with ILD and aimed to examine differential characteristics between patients with and without DM, including disease para...

Introduction: Primary hyperparathyroidism associated with multiple myeloma has been rarely reported to coincide, but relapse of previously remitted primary hyperparathyroidism concurrent with a plasma cell proliferative disorder has not been described.Case report: A 76-year-old female was referred to the endocrine clinic for evaluation of primary hyperparathyroidism discovered incidentally during hospitalization for angina. She had a corrected calcium of...

Introduction: PD-1 inhibitors are powerful disruptors of self- tolerance and autoimmune diabetes develops in up to 0.9% of patients. Lipodystrophic insulin reactions, although uncommon with human insulin analogs, are a recognized cause of impaired insulin delivery in patients on intensive insulin regimens. We describe a patient with resistant lymphoma and nivolumab-induced autoimmune diabetes, who suffered loss of glycemic control due to early radiation-induced subcutaneous fi...

Introduction: Ectopic Cushing’s Syndrome (ECS) accounts for 5-10% of all cases of endogenous hypercortisolism. ACTH secreting intrathoracic masses is the most common cause of ECS. We present two patients with ectopic Cushing’s syndrome, with particularities in diagnosis.Case 1:: A 59-year-old female presented with arterial hypertension, and osteoporosis, along with weight gain and facial plethora, starting two years before. Screening tests were...

Introduction: Stress is a known risk factor for the development of Graves’ disease. We have previously described the role of bereavement as an inducing factor for Graves’ disease. Bereavement as an inducing factor for Graves’ disease was shown to affect primarily female patients after the loss of a loved one. However, it appears that other stressful life events may also cause Graves’ disease.Aim: The aim of the study was to describe t...

Rare cases of Cushing’s syndrome have been diagnosed only based upon bone manifestations. Fracture risk is related to individual susceptibility to glucocorticoids that is genetically determined by several factors, including VDR gene polymorphism.We report three patients with VDR FokI gene polymorphism and multiple non-traumatic pathologic fractures as the presenting manifestation of Cushing’s syndrome.The second case is a...

Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation. The clinical behavior seems to be influenced by the neuroendocrine component. We report a patient with mixed adenoneuroendocrine carcinoma of cecum who presented 18 years after her initial diagnosis and treatment.Case report: A 59-year-old woman presented with a 3-month hist...

Introduction: Solid cell nests (SCNs) of the thyroid are considered embryological remnants of the ultimobranchial bodies and the thyroid diverticulum. They are frequently (61–89%) detected in the thyroid gland, but their biological significance remains disputable. According to the fetal cell thyroid carcinogenesis hypothesis SCNs may act as a source for specific thyroid cancer stem cells generating distinct thyroid cancer phenotypes. We report a case of a patient with con...

Introduction: Although the protective effects of 1,25(OH)2D3 on the early stages of atheromatosis process have been investigated, data on its influence on factors implicated in plaque vulnerability are limited. During these stages metalloproteinases MMP-2, MMP-9, their inhibitors TIMP-1,TIMP-2, the RANKL-RANK-OPG system and MCP-1 play a critical role. We aimed to investigate the effect of vitamin D on the expression of the above factors on endothelial cel...

Introduction: Glucocorticoids (GCs) are used in the treatment of chronic inflammatory or autoimmune diseases. However, patients are often resistant to the GC effects. Response to GCs is triggered through glucocorticoid receptor (GR). An important regulator of GR activity is the FKBP5. FKBP5 binds to co-chaperones promoting a conformation with lower cortisol affinity. The number of GRs is another determinant of GC sensitivity; GR expression is regulated by the nuclear ...